Frank Mills (born 1942) is a Canadian pianist.

Frank Mills may also refer to:

• Frank R. Mills (1870–1921), American stage and silent film actor
• Frank Mills (baseball) (1895–1983), American baseball catcher
• Frank Mills (British actor) (1927–2021), British actor
• Sir Frank Mills (diplomat) (1923–2006), British diplomat
• Frank Mills (physician) (1910–2008), Australian heart surgeon
• Frank Mills (politician) (1904–1969), member of the Ohio House of Representatives
• Frank Mills (rugby union) (1873–1925), Wales national rugby union player
• "Frank Mills", a song from the musical Hair