GDC may refer to:
- Democratic Group of the Centre (Romanian: Grupul Democrat de Centru), a political party in Romania
- Donaldson Center Airport, Greenville, South Carolina, United States
- Gabriel Dumont College, now Gabriel Dumont Institute, in Saskatchewan, Canada
- Gadolinium-doped ceria
- Gambia Democratic Congress, a political party in the Gambia
- Game Developers Conference, an annual video game conference
- General Development Corporation, a defunct American real estate company
- General Dental Council in the United Kingdom
- Genstar Development Company, a Canadian real estate developer
- Georgia Department of Corrections, of the U.S. state of Georgia
- Geothermal Development Company, in Kenya
- Giordano Dance Chicago, an American dance company
- Government degree colleges in India
- Graphic Display Calculator
- Gravity Discovery Centre, in Gingin, Western Australia
- Gross dealer concession
- Guglielmi detachable coil
- Society of Graphic Designers of Canada
- Virginia General District Court
- GDC, a compiler for the D programming language
- Global delivery center: IT services by a global company
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