George Knox may refer to:
- George Knox (MP, died 1827) (1765–1827), Irish member of the United Kingdom parliament
- George Knox (MP, died 1741), Irish MP for County Donegal
- Sir George Edward Knox (1845–1922), British judge in India
- Sir George Hodges Knox (1885–1960), Australian politician
- George L. Knox, escaped slave, activist, publisher and author
- George L. Knox II, U.S. Army Air Force officer and Tuskegee airman
- George William Knox (1853–1912), American theologian
- George Williams Knox (1838–1894), British soldier
- George A. Knox, zoologist and namesake of Mount Knox
See also
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