George Maddox may refer to:
- George Maddox (cricketer) (1811–1867), Australian cricketer
- Buster Maddox (George Woodrow Maddox, 1911–1956), player in the National Football League
- George Maddox (architect) (1760–1843), British architect and artist
- George Vaughan Maddox (1802–1864), British architect and builder
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