Grego is a surname. Notable people with the surname include:
- Antun Grego (born 1940), Croatian sailor
- Egidio Grego (1894–1917), Italian aviator
- Jim Grego (born 1955), American politician
- João Grego, 15th century Portuguese explorer
- Joseph Grego (1843–1908), English art collector
- Laura Grego, American physicist
- Melania Grego (born 1973), Italian water polo player
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