Grosse Ile (French: large island) or Grosse Isle may refer to:
Places in Canada
- Grosse Isle, Quebec, an island where many Irish Immigrants to Canada were housed and the site of the Grosse Isle Disaster
- Grosse-Île, Quebec, one of two municipalities forming the urban agglomeration of Îles-de-la-Madeleine in Quebec, Canada
- Grosse Isle, Manitoba, a small community in Manitoba, Canada
Places in the United States
- Grosse Ile Township, Michigan, United States
- Grosse Ile (Michigan), the largest island in the township
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