Grumbach or von Grumbach is a surname. Notable people with the surname include:
- Antoine Grumbach, French architect
- Argula von Grumbach (1492–1554?), Bavarian noblewoman
- Detlef Grumbach (born 1955), German author and journalist
- Doris Grumbach (1918–2022), American novelist, biographer, literary critic, and essayist
- Kevin Grumbach, American physician and academic
- Melvin M. Grumbach (1925–2016), American pediatrician and academic
- Wilhelm von Grumbach (1503–1567), German adventurer
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