Guadagnini is an Italian surname. Notable people with the surname include:
- Antonio Guadagnini (born 1966), Italian politician
- Giovanni Battista Guadagnini (1711 – 1786), Italian luthier
- Mattia Guadagnini (born 2002), Italian motocross rider
- Paolo Guadagnini (1908–1942), Italian violin maker
See also
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