HBD may refer to:
- "Happy birthday", see Happy Birthday (disambiguation)
- Hemoglobin subunit delta (HBD), a protein that in humans is encoded by the HBD gene
- Human biodiversity, see Human genetic variation
- HBD Venture Capital, a business incubator and venture capital founded by Mark Shuttleworth
- Station code for Hoshangabad railway station, Madhya Pradesh, India
- HB Dudelange, a handball club from Dudelange, Luxembourg
- HBD, Higher Banking Diploma offered by Emirates Institute for Banking and Financial Studies
- "HBD (Birthday Mo)", a song by Skusta Clee
- HBD, Howard Brothers Discount Stores
- Health Biotechnology Division (HBD), of the National Institute for Biotechnology and Genetic Engineering
- Hdb, IMA symbol for Humboldtine
- HBD, helicase binding domain, a domain of the DNA primase DnaG
- HbD, Hemoglobin D-Punjab
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