HDL may refer to one of the following:
- Hardware description language
- Harry Diamond Laboratories, a U.S. Army laboratory
- Handle System identifier (Hdl.handle.net)
- Headstone Lane railway station, London, National Rail station code
- High-density lipoprotein
- Les Hurlements d'Léo, an alternative rock band from France
- GE HDL diesel engine
- HDL System, HDL Universal Tactical role-playing game system produced by Tremorworks, LLC
- Huntington's disease-like syndromes, a family of genetic neurological diseases
- Huey, Dewey and Louie, Donald Duck's nephews
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