DEFA4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDEFA4, DEF4, HNP-4, HP-4, HP4, defensin alpha 4
External IDsOMIM: 601157 HomoloGene: 48059 GeneCards: DEFA4
Orthologs
SpeciesHumanMouse
Entrez

1669

n/a

Ensembl

ENSG00000164821
ENSG00000285318

n/a

UniProt

P12838

n/a

RefSeq (mRNA)

NM_001925

n/a

RefSeq (protein)

NP_001916

n/a

Location (UCSC)Chr 8: 6.94 – 6.94 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.[3][4] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria[5] and viruses.[6]

Function

Defensins are a peptide family of cytotoxic microbicides involved in innate immunity.[7] Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. DEFA4 differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.[3]

References

  1. 1 2 3 ENSG00000285318 GRCh38: Ensembl release 89: ENSG00000164821, ENSG00000285318 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 "Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (Homo sapiens)".
  4. Wu Z, Ericksen B, Tucker K, Lubkowski J, Lu W (September 2004). "Synthesis and characterization of human alpha-defensins 4-6". The Journal of Peptide Research. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502.
  5. Ericksen B, Wu Z, Lu W, Lehrer RI (January 2005). "Antibacterial activity and specificity of the six human {alpha}-defensins". Antimicrobial Agents and Chemotherapy. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305.
  6. Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, et al. (January 2005). "Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro". FEBS Letters. 579 (1): 162–6. doi:10.1016/j.febslet.2004.11.062. PMID 15620707. S2CID 84062495.
  7. Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI (October 1985). "Defensins. Natural peptide antibiotics of human neutrophils". The Journal of Clinical Investigation. 76 (4): 1427–35. doi:10.1172/JCI112120. PMC 424093. PMID 2997278.

Further reading

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