Hatzis or Chatzis (Greek: Χατζής) is a Greek surname with the female version being Hatzi or Chatzi (Χατζή). The name is derived from the honorific prefix Hatzi- designating people who visited the Holy Land. Notable people with the name include:

• Guido Hatzis, Greek-Australian comic character
• Efthimios Hatzis, Greek-American Film director
• Michalis Chatzis (born 1978), Greek footballer
• Nikos Chatzis (born 1976), Greek basketball player
• Tony Hatzis (born 1986), Australian footballer
• Vassileios Chatzis (1870–1915), Greek painter best known for his seascapes
• Dimitrios Hatzis (1913-1981), novelist and journalist.