High Frontier may refer to:
- The High Frontier, a 1976 book about space colonization by Gerard K. O'Neill
 - High Frontier, Inc., an American think tank established in the 1980s by former Lieutenant General Daniel O. Graham
 - High Frontier (video game), a 1987 video game by ZX Spectrum games
 - High Frontier (board game), a 2010 board wargame by Sierra Madre
 - The High Frontier (album), 2013 album by American band Lumerians
 
See also
- High Frontiers, former name of Mondo 2000, American magazine
 
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