Hufnagel (literally "hoof nail", metonymic occupational name for a farrier) is a surname. Notable people with the surname include:
- Charles A. Hufnagel (1916–1989), American surgeon
 - Johann Siegfried Hufnagel (1724–1795), German parson
 - John Hufnagel (born 1951), Canadian football player, coach, and executive
 - Kevin Hufnagel, American musician
 - Klaus Hufnagel (born 1955), East German track and field athlete
 - Leon Hufnagel (1893–1933), Polish astrophysicist
 - Tibor Hufnágel (born 1991), Hungarian sprint canoeist
 - Yanni Hufnagel (born 1982), American college basketball coach
 
See also
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