Isaacson is a surname meaning "son of Isaac", the Biblical figure. Notable people with the surname include:
- Doug Isaacson (born 1957), American politician
- Jacob Isaacson (1911–1980), American composer and musician
- James Isaacson (born 1980), English rugby union football player
- Megan Isaacson, American gospel singer
- Peter Isaacson (1920–2017), English-born Australian newspaper publisher and military pilot
- Rich Isaacson (born 1964), American music entrepreneur
- Richard A. Isaacson, American physicist and promoter of LIGO
- Thorpe B. Isaacson (1898–1970), American leader in The Church of Jesus Christ of Latter-day Saints
- Walter Isaacson (born 1952), American author, columnist and CEO
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