Itani is a surname. Notable people with the surname include:
- Ahmad Itani (born 1979), Lebanese football player
- Frances Itani (born 1942), Canadian fiction writer, poet and essayist
- Junichiro Itani (1926–2001), anthropologist and founder of Japanese primatology
- Kazuya Itani (born 1988), Japanese badminton player
- Muhieddine Itani (born 1929), Lebanese football player
- Munir Itani, Lebanese alpine skier and Olympian
- Ted Itani, retired Canadian military officer and humanitarian
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