Jackie O often refers to Jacqueline Onassis, who was the wife of the 35th President of the United States, John F. Kennedy.
It may also refer to:
- Jackie O (opera), a 1997 opera by Michael Daugherty and Wayne Koestenbaum
- Jackie O (radio host) (born 1975), Jacqueline Ellen Marie Henderson, an Australian television presenter and radio personality
- Jacki-O (born 1975), American rapper
- Jackie-O Motherfucker, an American experimental rock group
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