Jain is a surname of Indian origin and reflects the Jain religious community. Notable people with the surname include:
- Abigail Jain, actor
- Ajit Jain (born 1951), businessman
- Anand Jain (born 1957), business executive
- Anil Jain (disambiguation), several people
- Anjli Jain (born 1981), American businesswoman
- Anshu Jain (1963–2022), British Indian financier
- Bhagchandra Jain (born 1936), scholar
- Bhavarlal Jain (1937–2016), industrialist
- BM Jain, political scientist
- Dipak C. Jain (born 1957), business educator
- Jainendra K. Jain (born 1960), physicist
- Kalyan Jain (1934–2023), Indian politician
- Kamini Jain (born 1969), Canadian Olympic kayaker
- Meenakshi Jain, Indian political scientist and historian
- Naveen Jain (born 1959), Indian-American Internet entrepreneur
- Nirmal Jain (born 1967), Indian billionaire, founder of India Infoline
- Piyare Jain (1921–2019), Indian-American physicist
- Raj Jain (born 1951), Indian-American computer science professor
- Rakesh Jain (born 1950), Indian-American tumor biologist
- Ramesh Jain (born 1949), Indian-American computer science professor
- Ravindra Jain (1944–2015), Indian music composer, lyricist and playback singer
- S. Lochlann Jain, American author and anthropologist
- Sachin H. Jain (born 1980), American physician and policy analyst
- Sanjay Jain, Indian-British economist
- Sunny Jain (born 1975), American musician
- Tarang Jain (born 1962/63), Indian billionaire businessman
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