James Vaughn may refer to:
- Joseph Paul Franklin (1950–2013), American neo-Nazi and serial killer, born James Vaughn
- Hippo Vaughn (1888–1966), American baseball player, born James Leslie Vaughn
- James T. Vaughn (1925–2007), American politician and law enforcement officer
- James T. Vaughn Jr. (born 1949), American lawyer and judge
See also
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