José Varela may refer to:
- José Pedro Varela (1845-1879), Uruguayan politician
- José Pedro Varela, Uruguay, small Uruguayan city named after the politician
- José Gregorio Valera, Venezuelan president from 1878 to 1879
- José Enrique Varela (1891–1951), Spanish military commander
- José Luis Varela Lagunas (born 1946), Mexican politician
- José Varela Fernández (born 1954), Puerto Rican politician
- José Luis Varela (born 1978), Venezuelan boxer
- José Varela (cyclist) (born 1984), Costa Rican cyclist
- José Varela (footballer) (born 1997), Cape Verdean footballer
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