Joseph Locke (1805–1860) was a British civil engineer particularly associated with railway projects.
Joseph Locke may also refer to:
- Joe Locke (actor) (born 2003), a Manx actor
- Joe Locke (musician) (born 1959), an American jazz vibraphonist and composer
- Josef Locke (1917–1999), an Irish popular singer of the 1940s and 1950s
- Joseph Locke, penname of Ray Garton, an American author
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