Juan Medina may refer to:
- Juan José Medina, former President of Paraguay
- Juan Medina Herrad (born 1992), Dominican boxer
- Juan Antonio Medina (born 1946), former Spanish handball player
- Juan Carlos Medina (born 1983), Mexican footballer
- Juan de Medina (1490–1547), Spanish theologian and Spain's ambassador to Rome
- Juan Pablo Medina (born 1976), American actor
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