Karen Davis may refer to:
- Karen Davis (activist) (1944–2023), American animal-rights activist
- Karen Davis (neuroscientist), neuroscientist at University of Toronto, Canada
- Karen Davis (economist) (born 1942), president of The Commonwealth Fund
- Karen Davis (politician), former mayor of Glendora, California
- Karen Davis (The Grudge), a fictional character from The Grudge film series
See also
- Karen Davies (born 1965), golfer from Wales
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