Kayne is a given name. Notable people with the name include:
Given name
- Kayne Gillaspie (born 1979), American fashion designer, specializing in beauty pageant gowns
- Kayne Lawton (born 1989), Australian Rugby League player
- Kayne McLaggon (born 1990), Welsh footballer who plays as striker
- Kayne Pettifer (born 1982), Australian rules footballer in Australian Football League
- Kayne Robinson, American president of National Rifle Association
- Kayne Scott (born 1968), New Zealand racing driver
- Kayne Taylor, Australian pop music singer from Melbourne who won 2004 series of Popstars Live
- Kayne Vincent (born 1988), New Zealand football (soccer) player currently playing for Mumbai FC
Surname
- Richard Kayne (investor) (born 1945), American billionaire private equity asset manager
- Richard S. Kayne, American Professor of Linguistics and chair of Linguistics Department at New York University
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