Lambertini is an Italian surname that may refer to the following notable people:

• The Blessed Imelda Lambertini (1322–1333), patroness of First Holy Communicants
• 175629 Lambertini, a minor planet discovered in 2007 by F. Tozzi and M. Graziani
• Prospero Lambertini (1675–1758), Italian Cardinal elected Pope under the name Benedict XIV
• Attilio Lambertini (1920–2002), Italian racing cyclist
• Egano Righi-Lambertini (1906–2000), Italian Roman Catholic cardinal and Vatican diplomat
• Marta Lambertini (1937–2019), Argentine composer
• Michele di Matteo Lambertini (active 1447–1469), Italian painter active in Bologna