Leno is a surname. Notable people with the surname include:
- Bernd Leno (born 1992), German footballer
- Dan Leno (1860–1904), English music hall comedian
- Jay Leno (born 1950), American comedian, actor, voice actor, writer, producer, and television host
- John Bedford Leno (1826–1894), English radical activist
- Mark Leno (born 1951), United States politician
- Charles Leno Jr. (born 1991), NFL Offensive Lineman
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