Leontine may refer to:
- As a given name
- Leontine "Lona" Cohen (1913–1992), American spy for the Soviet Union
- Leontine Cooper (1837–1903), Australian trade unionist, suffragist and campaigner for women's rights
- Leontine T. Kelly (1920–2012), American bishop
- Leontyne Butler King (1905-1974), American businesswoman
- Léontine Lippmann (1844–1910), literary muse and salon hostess
- Léontine de Maësen (1835–1906), Belgian soprano
- Leontien van Moorsel (born 1970), Dutch racing cyclist
- Leontyne Price (born 1927), American soprano
- Leontine Sagan (1889–1974), Austrian actress
- As a middle name
- Florence Leontine Welch (born 1986) English singer
- Other uses
- Leontine martyrs, clergy killed in Persia in 455 AD
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