The following is a list of prominent Afro-Guyanese, or people of Afro-Guyanese descent.

Notable people of Afro-Guyanese descent

Letitia Wright, actress (Shuri in Black Panther)

• Deborah Cox, Canadian R&B singer-songwriter with longest-running #1 R&B track on charts
• Jason David, Canadian-born American football cornerback
• JDiggz, Canadian rapper, Afro-Guyanese mother
• Melanie Fiona, Canadian R&B singer-songwriter, who is also of Indo-Guyanese descent
• Nubya Garcia, English saxophonist and jazz musician, Guyanese mother
• David Lammy, British-born politician and lawyer
• Tessa McWatt, Guyanese-born Canadian writer
• Des'ree, English singer, Afro-Guyanese mother
• Sonnet L'Abbé, Canadian writer
• Yolanda T. Marshall, Guyanese-born Canadian writer
• Dawnn Lewis, American actress
• Leona Lewis, singer and the first winner of "The X Factor" (series 3), Guyanese father
• Jermain Jackman, singer and "The Voice UK" (2015) winner
• Derek Luke, American actor
• Maestro, Canadian rapper and actor
• Nicole Narain, Playboy model, has an Afro-Guyanese mother and her father, who is of mixed Indo-Guyanese and Chinese-Guyanese descent
• Trevor Phillips, British politician
• Joy Reid, American news correspondent for MSNBC, Afro-Guyanese mother
• Rihanna, Barbados-born singer/billionaire, Afro-Guyanese mother
• Saukrates, Canadian rapper/singer
• Eon Sinclair, bassist of Canadian rock/ska/reggae band Bedouin Soundclash
• Sean Patrick Thomas, actor (Save the Last Dance and Barbershop)
• Phil Lynott, English-born frontman of the Irish rock band Thin Lizzy, Afro-Guyanese father
• Wretch 32, British rapper, Guyanese mother
• Vanessa Lee Chester, former American child actress ("A Little Princess", "Harriet the Spy", and "The Lost World: Jurassic Park")
• Letitia Wright, actress, who is best-known for playing Shuri in the 2018 film version of "Black Panther" and the 2022 sequel "Black Panther: Wakanda Forever"
• Roy Woods, Canadian R&B artist
• Saint JHN, Guyanese-American rapper
• Shaunette Renée Wilson, Guyanese-born American actress ("The Resident", "Billions", and "Black Panther")

Arts

Eddy Grant, musician

• Eddy Grant, musician
• Ram John Holder, actor and musician
• Colle´ Kharis, Reggae recording artist
• Preme, Canadian rapper
• Red Café, Guyanese-American rapper

Sports

Ezekiel Jackson, Professional wrestler

• Clifford Anderson, former British Empire featherweight contender
• Basil Butcher, former Guyanese and West Indian cricketer
• Colin Croft, former Guyanese and West Indian cricketer
• Chelsea Edghill, Guyanese table tennis player
• Roy Fredericks, former Guyanese and West Indian cricketer
• Lance Gibbs, former Guyanese and West Indian cricketer
• Vivian Harris, former WBA super lightweight champion
• Roger Harper, former Guyanese and West Indian cricketer
• Carl Hooper, former West Indian cricket captain
• Ezekiel Jackson, professional wrestler
• Clayton Lambert, American, Guyanese and West Indian cricketer, scored the most runs for Guyana
• Andrew Lewis, former WBA welterweight champion
• Clive Lloyd, former Guyanese and West Indian cricketer
• Aliann Pompey, Guyanese 400 meter sprinter
• Alana Shipp - Barbadian IFBB professional bodybuilder
• Mark McKoy, Guyanese-born Canadian sprinter

Politicians and social leaders

Forbes Burnham, President of Guyana from 1980 to 1985

Hamilton Green, 1st Muslim Prime Minister of Guyana, and in the Western world, 1985-1992

• Forbes Burnham, President of Guyana, 1980-1985
• Hubert Nathaniel Critchlow, father of the trade union movement in British Guiana
• Cuffy, leader of the Berbice slave uprising
• Karen de Souza (born 1958), women and children's activist
• Jack Gladstone, leader of the Demerara rebellion of 1823
• David A. Granger, President of Guyana
• Hamilton Green, 1st Muslim Prime Minister of Guyana, and in the Western world, 1985-1992
• Desmond Hoyte, President of Guyana, 1985-1992
• Sam Hinds, former President of Guyana, Prime Minister of Guyana
• Eusi Kwayana, former Guyanese cabinet member and veteran politician
• Lincoln Lewis, trade union leader
• Quamina, leader of the Demerara rebellion of 1823
• Ptolemy Reid, former Prime Minister of Guyana

Academics

Ivan Gladstone Van Sertima, associate professor of Africana Studies at Rutgers University

• John Agard, playwright, poet and children's writer
• George Granville Monah James, historian and author
• Egbert Martin, 19th-century Guyanese poet of mixed African and European ancestry
• Walter Rodney, historian and political activist
• Ivan Gladstone Van Sertima, associate professor of Africana Studies at Rutgers University

Models

• Arti Cameron