This is the list of Schedule II controlled substances as defined by the United States Controlled Substances Act.[1] The following findings are required for substances to be placed in this schedule:[2]

  1. The drug or other substance has a high potential for abuse.
  2. The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.
  3. Abuse of the drug or other substances may lead to severe psychological or physical dependence.

The complete list of Schedule II substances is as follows. The Administrative Controlled Substances Code Number and Federal Register citation for each substance is included.

ACSCNClassDrug
9050 opiate Codeine[3]
9334 opiate Dihydroetorphine[4]
9190 opiate Ethylmorphine[3]
9059 opiate Etorphine hydrochloride[5]
9640 opiate Granulated opium[3]
9193 opiate Hydrocodone[3]
9150 opiate Hydromorphone[3]
9260 opiate Metopon[3]
9300 opiate Morphine[3]
9668 opiate Noroxymorphone[6]
9610 opiate Opium extracts[3]
9620 opiate Opium fluid[3]
9330 opiate Oripavine[7]
9143 opiate Oxycodone[3]
9652 opiate Oxymorphone[3]
9639 opiate Powdered opium[3]
9600 opiate Raw opium[3]
9333 opiate Thebaine[3]
9630 opiate Tincture of opium[3]
opiate Opium poppy and poppy straw[8][note 1]
9040 stimulant Coca, leaves and any salt, compound, derivative or preparation of coca leaves[8][note 1]
9041 stimulant Cocaine, and its salts, isomers, derivatives and salts of isomers and derivatives[8][note 1]
9180 stimulant Ecgonine, and its salts, isomers, derivatives and salts of isomers and derivatives[8][note 1]
9670 opiate Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy)[9]
9737 opiate Alfentanil[10]
9010 opiate Alphaprodine[8][note 1]
9020 opiate Anileridine[8][note 1]
9800 opiate Bezitramide[8][note 1]
9273 opiate Bulk dextropropoxyphene (non-dosage forms)[11]
9743 opiate Carfentanil[12]
9120 opiate Dihydrocodeine[8][note 1]
9170 opiate Diphenoxylate[8][note 1]
9801 opiate Fentanyl[8][note 1]
9226 opiate Isomethadone[8][note 1]
9648 opiate Levo-alphacetylmethadol[13]
9210 opiate Levomethorphan[8][note 1]
9220 opiate Levorphanol[8][note 1]
9240 opiate Metazocine[8][note 1]
9250 opiate Methadone[8][note 1]
9254 opiate Methadone intermediate[8][note 1]
9802 opiate Moramide intermediate[8][note 1]
9245 opiate Oliceridine[14]
9230 opiate Pethidine (meperidine)[8][note 1]
9232 opiate Pethidine intermediate A[8][note 1]
9233 opiate Pethidine intermediate B[8][note 1]
9234 opiate Pethidine intermediate C[8][note 1]
9715 opiate Phenazocine[8][note 1]
9730 opiate Piminodine[8][note 1]
9732 opiate Racemethorphan[8][note 1]
9733 opiate Racemorphan[8][note 1]
9739 opiate Remifentanil[15]
9740 opiate Sufentanil[16]
9780 opiate Tapentadol[17]
9729 opiate Thiafentanil[18]
1100 stimulant Amphetamine, its salts, optical isomers, and salts of its optical isomers[19]
1105 stimulant Methamphetamine, its salts, isomers, and salts of its isomers[19]
1631 stimulant Phenmetrazine and its salts [20]
1724 stimulant Methylphenidate[20]
1205 stimulant Lisdexamfetamine, its salts, isomers, and salts of its isomers[21]
2125 depressant Amobarbital[22]
2550 depressant Glutethimide[23]
2270 depressant Pentobarbital[22]
7471 depressant Phencyclidine[24]
2315 depressant Secobarbital[22]
7379 hallucinogen Nabilone[25]
7365 hallucinogen Dronabinol oral solution[26]
8501 precursor Phenylacetone[27]
7460 precursor 1-phenylcyclohexylamine[27]
8603 precursor 1-piperidinocyclohexanecarbonitrile (PCC)[27]
8333 precursor 4-anilino-N-phenethyl-4-piperidine (4-ANPP)[28]
8366 precursor Norfentanyl[29]

Notes

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 This substance was expressly scheduled by the Controlled Substances Act on October 27, 1970. The 1974 Federal Register ruling (by Administrator John R. Bartels, Jr.) merely organized its listing in the Code of Federal Regulations.

References

  1. ↑ "21 C.F.R. 1308.12 (Schedule II)". Code of Federal Regulations. Retrieved September 7, 2023.
  2. ↑ 21 U.S.C. § 812(b)(4) retrieved October 7, 2007
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Ingersoll, John (September 29, 1971). "Schedules of Controlled Substances: Removal of Naloxone From Control" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived from the original (PDF) on September 16, 2021. Retrieved September 7, 2023.
  4. ↑ Mercado, Julio (November 17, 2000). "Schedule II Control of Dihydroetorphine Under the Controlled Substances Act". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
  5. ↑ Bartels, Jr., John R. (March 29, 1974). "Etorphine Hydrochloride Transfer to Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on September 26, 2021. Retrieved September 7, 2023.
  6. ↑ Dhillon, Uttam (August 16, 2019). "Listing of Noroxymorphone in the Code of Federal Regulations and Assignment of a Controlled Substances Code Number". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
  7. ↑ Leonhart, Michele (September 24, 2007). "Designation of Oripavine as a Basic Class of Controlled Substance". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
  8. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Bartels Jr., John R. (June 20, 1974). "PART 1308— SCHEDULES OF CONTROLLED SUBSTANCES: Annual Publication" (PDF). Government Publishing Office. Drug Enforcement Administration. Archived from the original (PDF) on September 6, 2023. Retrieved September 6, 2023.
  9. ↑ Bartels, Jr., John R. (February 14, 1975). "Concentrate of Poppy Straw, Addition to Schedule II and Authorizing its Importation" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on September 26, 2021. Retrieved September 7, 2023.
  10. ↑ Lawn, John (January 23, 1987). "Rescheduling of Alfentanil from Schedule I to Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on July 28, 2019. Retrieved September 7, 2023.
  11. ↑ Bensinger, Peter (July 22, 1980). "Control of Bulk Dextropropoxyphene (Non-dosage Forms) in Schedule II as an Opiate" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on March 24, 2016. Retrieved September 7, 2023.
  12. ↑ Lawn, John (October 28, 1988). "Placement of Carfentanil into Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on March 22, 2016. Retrieved September 7, 2023.
  13. ↑ Bonner, Robert (August 18, 1993). "Schedules of Controlled Substances; Transfer of Levo-acetylmethadol from Schedule I into Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on July 28, 2019. Retrieved January 16, 2023.
  14. ↑ Evans, D. Christopher (July 12, 2021). "Schedules of Controlled Substances: Placement of Oliceridine in Schedule II". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
  15. ↑ Milford, Jr., James S. (November 5, 1996). "Schedules of Controlled Substances: Placement of Remifentanil Into Schedule II". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  16. ↑ Mullen, Jr., Francis M. (May 25, 1984). "Schedules of Controlled Substances; Rescheduling of Sufentanil into Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on May 19, 2019. Retrieved January 16, 2023.
  17. ↑ Leonhart, Michele (May 21, 2009). "Schedules of Controlled Substances: Placement of Tapentadol Into Schedule II". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  18. ↑ Dhillon, Uttam (June 10, 2019). "Schedules of Controlled Substances: Placement of Thiafentanil in Schedule II". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
  19. 1 2 Ingersoll, John (July 7, 1971). "Amphetamine, Methamphetamine, and Optical Isomers" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  20. 1 2 Finlator, John (October 28, 1971). "Phenmetrazine and its salts, and Methylphenidate" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  21. ↑ Leonhart, Michele (May 3, 2007). "Schedules of Controlled Substances: Placement of Lisdexamfetamine Into Schedule II". Federal Register. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
  22. 1 2 3 Bartels, Jr., John R. (November 13, 1973). "Schedule II Control of Amobarbital, Pentobarbital, Secobarbital, and their salts" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  23. ↑ Bonner, Robert (March 21, 1991). "Schedules of Controlled Substances: Transfer of Glutethimide from Schedule III to Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  24. ↑ Bensinger, Peter (January 25, 1978). "Placement of Phencyclidine in Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  25. ↑ Lawn, John (April 7, 1987). "Placement of Nabilone in Schedule II" (PDF). Government Publishing Office. Drug Enforcement Administration. p. 11042. Archived from the original (PDF) on April 30, 2023. Retrieved September 7, 2023.
  26. ↑ Patterson, Robert (November 22, 2017). "Schedules of Controlled Substances: Placement of FDA-Approved Products of Oral Solutions Containing Dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] in Schedule II". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
  27. 1 2 3 Bensinger, Peter (February 11, 1980). "Schedules of Controlled Substances; Schedule II Placement of Phenylacetone; (Phenyl-2-propanone, P2P, methyl benzyl ketone, benzyl methyl ketone)" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  28. ↑ Leonhart, Michele (June 29, 2010). "Control of Immediate Precursor Used in the Illicit Manufacture of Fentanyl as a Schedule II Controlled Substance". Federal Register. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
  29. ↑ Dhillon, Uttam (April 17, 2020). "Control of the Immediate Precursor Norfentanyl Used in the Illicit Manufacture of Fentanyl as a Schedule II Controlled Substance". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
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