Route 185 or Highway 185 may refer to:

Canada

• Quebec Route 185

India

• National Highway 185 (India)

Ireland

• R185 road (Ireland)

Japan

• Japan National Route 185

Poland

• Voivodeship road 185

United States

• Interstate 185
• U.S. Route 185 (former)
• Alabama State Route 185
• Arkansas Highway 185
• California State Route 185
• Connecticut Route 185
• Florida State Road 185 (former)
• Georgia State Route 185
• Hawaii Route 185
• Illinois Route 185
• K-185 (Kansas highway)
• Kentucky Route 185
• Maine State Route 185
• Maryland Route 185
• M-185 (Michigan highway)
• Missouri Route 185
• New Jersey Route 185
• New Mexico State Road 185
• New York State Route 185
• Ohio State Route 185
• Pennsylvania Route 185 (former)
• South Carolina Highway 185
• Tennessee State Route 185
• Texas State Highway 185
  • Texas State Highway Spur 185
  • Farm to Market Road 185 (Texas)
  • Urban Road 185 (Texas, signed as Farm to Market Road 185)
• Utah State Route 185 (former)
• Virginia State Route 185
• Wisconsin Highway 185

Territories

• Puerto Rico Highway 185