The following highways are numbered 288:

Japan

Japan National Route 288

Sweden

• Länsväg 288 between Uppsala, Gimo and Östhammar

United States

• Arizona State Route 288
• Georgia State Route 288
• Kentucky Route 288
• Maryland Route 288
• Minnesota State Highway 288 (former)
• Montana Secondary Highway 288
• New Mexico State Road 288
• New York State Route 288 (former)
• Ohio State Route 288
• Pennsylvania Route 288
• South Carolina Highway 288
• Tennessee State Route 288
• Texas State Highway 288
  • Texas State Highway Loop 288
  • Farm to Market Road 288 (Texas)
• Utah State Route 288 (former)
• Virginia State Route 288