The following highways are numbered 421:
Canada
- Manitoba Provincial Road 421
- Newfoundland and Labrador Route 421
Japan
United States
- U.S. Route 421
- Florida State Road 421
- Georgia State Route 421 (unsigned designation for Interstate 516)
- New Mexico State Road 421
- New York State Route 421
- Ohio State Route 421
- Puerto Rico Highway 421
- South Carolina Highway 421
- Tennessee State Route 421
- Texas State Highway Spur 421
Preceded by 420 |
Lists of highways 421 |
Succeeded by 422 |
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