Louis of Blois can refer to:
- Louis I, Count of Blois (1172–1205), Count of Blois and participant in the Fourth Crusade
- Louis II, Count of Blois (died 1346), Count of Blois and lord of Avesnes
- Louis III, Count of Blois (died 1372), Count of Blois and lord of Avesnes
- Louis de Blois (1506–1566), French mystical writer
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