Luini is a surname. Notable people with the surname include:
- Aurelio Luini (c. 1530-1593), Italian painter and draughtsman
- Bernardino Luini (c. 1480/82–1532), Italian painter
- Elia Luini (born 1979), Italian rower
- Giulio Cesare Luini (1512- after 1565), Italian painter
- Sergio Luini (born 1972), Italian Olympic gymnast
- Sofía Luini (born 1992), Argentine tennis player
- Tommaso Luini, Italian painter
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