MGB may refer to:
- Game Boy Pocket (product code MGB-001) and Game Boy Light (product code MGB-101), portable gaming devices by Nintendo
- Mathematical Gymnasium Belgrade (Matematička Gimnazija), an elementary and high school for gifted students in Serbia
- Magandang Gabi, Bayan, a news program in the Philippines
- Matterhorn Gotthard Bahn, a railroad operating in the Swiss Alps
- Matthew Good Band, a Canadian group
- Medial geniculate nucleus, or medial geniculate body, a subnucleus of the thalamus in the brain
- Medium Girder Bridge, a modular, military bridge
- MG MGB, a sports car produced by the British Motor Corporation and its successors from 1962 to 1980
- Mines and Geosciences Bureau, a government agency in the Philippines
- Ministry for State Security (Soviet Union) (Ministerstvo Gosudarstvennoi Bezopasnosti), a predecessor of the KGB
- Motor Gun Boat, a fast attack boat armed with cannons and guns, as opposed to the Motor Torpedo Boat
- Mount Gambier Airport, an airport servicing the Mount Gambier region which uses the IATA code MGB
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