MTL may refer to:
- An abbreviation and nickname for the city of Montréal, Quebec
- The Montreal Canadiens, a National Hockey League (NHL) team based in Montreal, Quebec
- C.F. Montréal, a Major League Soccer team based in Montréal.
- The Montréal Alouettes, a Canadian Football League (CFL) team based in Montréal, Quebec.
- An abbreviation of Mount Laurel Township, New Jersey
- The official abbreviation for the Muldentalkreis district in the Free State of Saxony, Germany
- The ISO 4217 code for the Maltese lira, the former currency of Malta
- Modern Taiwanese Language, an orthography in the Latin alphabet for the Taiwanese language
- First language or mother tongue language
- Master of Teaching and Learning postgraduate degree
- Mary Todd Lincoln (1818–1882), wife of Abraham Lincoln and the First Lady of the United States
- Maitland Airport in Australia
- Mortlake railway station in London, England (National Rail station code)
- RAF-Avia, ICAO code
- An initialism for Military Training Leader
- Marc Tessier-Lavigne, the 11th President of Stanford University
Science and technology
- Machine translation, often abbreviated as "MTL"
- Material Template Library, a 3D graphics format that describes the material(s) for an accompanying OBJ file
- Matrix Template Library, a linear algebra library for C++ programs
- Meteor Lake, a CPU lineup from Intel
- Microsystems Technology Laboratories at the Massachusetts Institute of Technology
- Model transformation language, a generic term for various languages to perform transformations on mathematical models
- Monoidal t-norm logic, the logic of left-continuous t-norms
- Japan Median Tectonic Line, Japan's largest seismic fault system
- Medial temporal lobe, a brain region involved in learning and memory
- Merged transistor logic
- Metric temporal logic
- Multi-task Learning
- MTL Harbor Tugboats
Products and companies
- Modern Terminals Limited, a container terminal operator in Hong Kong
- MTL (transport company), a former Merseyside-based bus, coach and train operator in the United Kingdom
- MTL Instruments Group
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