Mafa is a local government area of Borno State, Nigeria.
Mafa or MAFA may also refer to:
- MAFA (Mast cell function-associated antigen), a type II membranal glycoprotein
- MAFA (gene) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)), a human gene
- MafA, a type of MAF (gene), a human transcription factor
- Mafa (bug), a genus of lace bugs
- Mafa language, an Afro-Asiatic language spoken in northern Cameroon and eastern Nigeria
- Manchester Academy of Fine Arts in England
- Melaka Football Association, a football association in Malaysia
- Victorian Amateur Football Association, previously the Metropolitan Amateur Football Association, an Australian rules football competition
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