Malcolm Stevens

OBE, FRS
Born
Malcolm Francis Graham Stevens

1938 (age 85–86)
CitizenshipBritish
EducationBolton School
Alma materUniversity of Nottingham
SpouseValerie Deans (m.1961)

Malcolm Francis Graham Stevens OBE, FRS (born 1938)[1] is an English chemist and Emeritus professor of the University of Nottingham, having previously worked at Aston University where he developed the cancer drug temozolomide.[2][3]

Education and family

Stevens attended Bolton School, Lancashire, and then obtained a BSc and PhD at the University of Nottingham.[4]

He married Valerie Deans at Christ Church, Heaton, Bolton, in 1961.[5][6]

Career

Stevens took up a post of Reader in the Department of Pharmaceutical Sciences at Aston University in 1972, and was later appointed Professor. He was a member of the Cancer Research UK Experimental Cancer Chemotherapy group from 1980 to 2006, moving to the University of Nottingham in 1992.[3][7] Stevens's lab synthesised Temozolomide, which as of 2019, remains the only FDA-approved drug to treat the deadly brain tumor Glioblastoma multiforme. Temozolomide has had a substantial impact in the clinic: the 5-year survival with radiation alone is 4%, whilst with radiation plus temozolomide, it approaches 17%. The 10 year survival without temozolomide is <1% versus around 8% with temozolomide. Thus, long term survivorship with GBM is now possible (if not common), thanks to the work of Stevens and his group.[8][9]

Recognition

Stevens was appointed OBE in the 1999 New Year Honours "For services to the development of Cancer Drugs", being described as "Professor of Experimental Cancer Chemotherapy, University of Nottingham".[10] He was elected a Fellow of the Royal Society in 2009.[2]

References

  1. ↑ "Birth index entry". FreeBMD. ONS. September 1961. Retrieved 6 September 2017.
  2. 1 2 "Malcolm Stevens". The Royal Society. Retrieved 5 September 2017.
  3. 1 2 "Malcolm Stevens". School of Pharmacy. University of Nottingham. Retrieved 5 September 2017.
  4. ↑ "100 Inspiring Minds – Professor Malcolm Stevens OBE, FRS". Bolton School. Archived from the original on 6 September 2017. Retrieved 5 September 2017.
  5. ↑ "Marriage index entry". FreeBMD. ONS. September 1961. Retrieved 6 September 2017.
  6. ↑ "Marriage Indexes". lancashirebmd.org.uk. Retrieved 6 September 2017.
  7. ↑ "Professor Malcolm Stevens OBE, FRS". 50 Aston Greats. Aston University. Retrieved 5 September 2017.
  8. ↑ Weller, Michael; et al. (17 June 2019). "How we treat glioblastoma". ESMO Open. 4 (Suppl 2): e000520. doi:10.1136/esmoopen-2019-000520. PMC 6586206. PMID 31297242.
  9. ↑ Stupp, Roger; et al. (10 March 2005). "Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma". New England Journal of Medicine. 352 (10): 987–996. doi:10.1056/NEJMoa043330. PMID 15758009.
  10. ↑ "No. 55354". The London Gazette (Supplement). 31 December 1998. p. 13.
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