Mane or Mané is a surname. Notable people with the surname include:
- Ansumane Mané (1940–2000), Guinea-Bissau soldier
- Carlos Mané (born 1994), Portuguese footballer
- Gucci Mane (born 1980), American rapper; birth name Radric Davis
- Emmanuel Mane-Katz (1894–1962), Ukrainian painter
- Laxman Mane (born 1949), Indian writer and a social activist
- Malick Mané (born 1988), Senegalese football player
- Nivedita Sambhajirao Mane (born 1963), Indian politician
- Purnima Mane, Indian public health worker
- Sadio Mané (born 1992), Senegalese footballer
- Sureshbabu Mane (1902–1953), Indian singer
- Tyler Mane (born 1966), Canadian actor and professional wrestler
- Vinayak Mane (born 1982), Indian cricketer
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