Margaret Clarke may refer to:
- Margaret Clarke (artist) (1888–1961), Irish portrait painter
- Margaret Clarke (chess) (1937–2018), British chess player
- Margaret Turner Clarke (1836–1887), Australian nurse
- Margaret Clarke (actress), in Espedair Street
- Margaret Clarke (camogie), see All-Ireland Senior Camogie Championship 1959
See also
- Margaret Clark (disambiguation)
- Maggie Clarke, environmental scientist
- Peggy Clarke (disambiguation)
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