People known as Margaret of Sicily:
- Margaret of Navarre (1135–1183), wife of William I of Sicily
- Margaret of Sicily (1241–1270), daughter of Frederick II, King of Sicily
- Margaret of Burgundy, Queen of Sicily, (1250–1308), wife of Charles of Anjou, King of Sicily
- Margaret of Sicily, Countess Palatine of the Rhine (1331–1377), daughter of the King Frederick III of Sicily
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