Marsicano is a surname. It may refer to:
- Alberto Marsicano (1952–2013), Brazilian musician, translator, writer, philosopher and professor
- Michael Marsicano (born 1956), American entrepreneur, President and CEO of Foundation For The Carolinas
- Nicholas Marsicano (1908–1991), American painter and university teacher
- Trevor Marsicano (born 1989), American speed skater and Olympian
- Claudia Marsicano (born 1992),Italian actress
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