Mazel is a surname. Notable people with the surname include:
- Eugène Mazel (1828–1890), French amateur botanist
- Ilya Mazel (aka Ruvim Mazel, 1890–1967), Soviet painter
- Isaak Mazel (1911–1945), Soviet chess master
- Judy Mazel (1943–2007), American weight loss advocate and author of The Beverly Hills Diet
- Leo Mazel (1907–2000), Soviet-Russian musicologist
- Maurice Mazel, prominent Chicago surgeon who founded Edgewater Hospital
- Olivier Mazel (1858–1940), French Army general during World War I
- Zvi Mazel (born 1939), Israeli diplomat
Mazel can also refer to:
- Luc Maezelle (born 1931), Belgian comic artist
See also
- Mazel Group Engineering, a Barcelona based design studio specialising in concept cars and engineering solutions
- Mazel tov
- Maazel
- Mazenzele, Flemish village in the Belgian province Flemish-Brabant
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