Mazzoli is an Italian surname. Notable people with the surname include:
- Missy Mazzoli (born 1980), American opera composer
- Romano L. Mazzoli (1932–2022), American politician and lawyer
- Athirson Mazolli e Oliveira (born 1977), Brazilian footballer
- Estrella Mazzoli de Mathov, Argentine physicist
See also

Wikimedia Commons has media related to Mazzoli (surname).
- Immigration Reform and Control Act of 1986 aka Simpson-Mazzoli Act
- Mazzuoli (disambiguation)
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