McGilligan is a surname. Notable people with the surname include:
- Brian McGilligan (born 1963), Irish hurler and Gaelic footballer
- Janak Palta McGilligan, Indian social worker
- Patrick McGilligan (Fine Gael politician) (1889–1979), Irish lawyer and politician
- Patrick McGilligan (biographer), American writer
- Patrick McGilligan (Irish nationalist politician) (1847–1917), Irish nationalist politician
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