McGriff is a surname. Notable people with the surname include:
- Curtis McGriff (born 1958), American former National Football League player
- Edna McGriff (1935–1980), American rhythm-and-blues singer
- Fred McGriff (born 1963), American former Major League Baseball player
- Hershel McGriff (born 1927), American stock car racing driver
- Jimmy McGriff (born 1936), American hard-bop and soul-jazz organist and organ trio bandleader
- Kenneth McGriff (born 1959), American drug trafficker and organized crime figure
- Lee McGriff (born 1953), American former football player
- Michael McGriff, 21st century American poet
- Perry McGriff (1937–2017), an American politician
- Terry McGriff (born 1963), American former Major League Baseball player
- Travis McGriff (born 1976), American former National Football League and Arena Football League player
- Tyrone McGriff (1958–2000), American former National Football League player
Fictional Character
- Selene McGriff, a fictional character from Mobile Suit Gundam SEED C.E. 73: Stargazer
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