Mederos is a Spanish-language surname. Notable people with the surname include:
- Enrique Mederos (1967–2004), Mexican voice actor
- Manuel de Mederos (1539 – c. 1613), Portuguese explorer
- Rene Mederos (1933–1996), Cuban artist
- Rodolfo Mederos (born 1940), Argentine musician
- Rogel Lazaro Aguilera-Mederos, a truck driver responsible for the 2019 Lakewood semi-truck crash
See also
- Medeiros (disambiguation), the Portuguese-language variant
- Medero
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