A medicine show is a traveling act that uses entertainment to sell patent medicines.

Other uses of the term include:

Comedy

• "The Medicine Show", a 1933 Krazy Kat cartoon
• "The Pink Medicine Show", a 1978 sketch comedy program featuring Rob Buckman

Fiction

• InterGalactic Medicine Show, an online science fiction magazine
  • Orson Scott Card's InterGalactic Medicine Show , an anthology of material originally published in it
• Medicine Show, a 1994 novel by Jody Lynn Nye

Drama

• "Medicine Show", a 1952 episode of The Adventures of Wild Bill Hickok
• "Medicine Show", a 1958 episode of Union Pacific
• "The Great American Medicine Show", a 1993 episode of Dr. Quinn, Medicine Woman

Music

• Medicine Show, a 1984 album by The Dream Syndicate
• The Medicine Show, a 2019 album by Melissa Etheridge
• Madlib Medicine Show, a series of albums by Madlib
• Medicine Show Man, a 1964 album by Pink Anderson
• "Medicine Show", a 1985 song by Big Audio Dynamite
• "The W.S. Walcott Medicine Show, a 1970 song by Robbie Robertson
• "The Incredible Medicine Show", a song by Moxy Früvous from their 1997 album You Will Go to the Moon
• Old Crow Medicine Show, a string band
  • Old Crow Medicine Show (album), their 2004 album
• Dr. West's Medicine Show and Junk Band, a psychedelic rock band
• Dr. Hook & the Medicine Show, a rock band
• MV & EE, a neo-psychedelic band who also recorded under the name "MV & EE Medicine Show"