Methodius or Methodios may refer to:

• Methodius of Olympus (d. 311), Christian bishop, church father, and martyr
• Apocalypse of Pseudo-Methodius, a seventh-century text purporting to be written by Methodius of Olympus
• Methodios I of Constantinople (c. 790–847), patriarch of Constantinople
• Saint Methodius of Thessaloniki (826–885), Byzantine Greek archbishop of Moravia and scholar, associated with Cyril
• Methodius II of Constantinople, Ecumenical Patriarch in 1240
• Methodius III of Constantinople, Ecumenical Patriarch in 1668–1671
• Methodios Anthrakites (1660–1736), Greek scholar, priest and director of the Gioumeios and Epiphaneios Schools in Ioannina
• Metodyj Trochanovskij (1885–1947), Polish activist
• Metropolitan Methodios (Tournas) of Boston (born 1946), the spiritual leader of the Greek Orthodox Metropolis of Boston
• Methodius Buslaev, fictional character from Dmitri Yemets's book series
• St. Methodios Faith and Heritage Center, a camp run by the Greek Orthodox Metropolis of Boston located in the town of Hopkinton, New Hampshire, United States
• Methodius, Berat's archbishop, who renovated the Ardenica Monastery in 1743