Mike or Michael Powers may refer to:
- Mike Powers (baseball) (1906–1983), American right fielder in Major League Baseball
- Mike Powers (soccer) (born 1957), retired American soccer midfielder
- Mike Powers (politician) (born 1962), American politician in Wisconsin
- Doc Powers (Michael Riley Powers, 1870–1909), American Major League Baseball player
- Michael R. Powers (born 1959), American professor of insurance and author
- Mike Powers, county executive officer in the Ventura County, California#Government.
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